The Natchez Museum of African American History and Culture is a museum located in Natchez, Mississippi. The museum chronicles the history and culture of African Americans in the southern United States. The museum was first opened in 1991 by the Natchez Association for the Preservation of African American Culture, also known as NAPAC, an organization dedicated to exploring the societal contributions made by people of African origin and descent.

The museum showcases events starting with the incorporation of the City of Natchez in 1716 to the present, using art, photographs, manuscripts, artifacts, and books. Exhibits cover the era of slavery, the Civil War, Reconstruction, 20th Century wars and the Civil rights era. They include Forks of the Road, which was the second largest slave market in the southern United States, and which has received international recognition by the United Nations because of its role in the international slave trade; The Rhythm Nightclub fire, where over 200 African American Natchez citizens died; an exhibit dedicated to the literary works of critically acclaimed author Richard Wright, a Natchez native. The museum also hosts educational events and presentations.

In February 2016, as part of its participation in Black History Month events, the Museum held its inaugural Natchez Hip Hop Summit, with Hip hop music performances and a panel discussion on hip hop in relation to racial identity.

Address: 301 Main Street, Natchez, MS
Phone: (601) 445-0728
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Directors: Darrell White, napacmuseum@cableone.net